Research fields. Concepts:
Complex human phenotypes and diseases are determined by genetics and the environment.
Whereas hereditary influences are considered to be significant, simple single nucleotid Polymorphisms (SNPs) are obviously not of high influence. Gene- environment interactions underlying epigenetics may be of special importance.
Epigenetics is regulated by three main mechanisms, CpG Methylation,Histone modifications, Interference DNA
We think that nutrition affects basic human molecular function such as ageing, gut health, CNS -functions, oxydation, inflammation, DNA damage, DNA repair via the epigenetic system in two ways:
1. directly, by epigenetic and anti-oxidative effects of food ingredients
2. indirectly, by changing gut microbiota and their epigenetic active metabolites
Interaction between GI microbiota, the gut, the immune system and the gut brain axis are of central importance
for human health and healthy ageing
Epigenetic regulation of telomer attrition, anti-oxydative and inflammatory mechanisms, DNA instability and DNA repair as well as inbalances of GI microbiota is of central importance for health. Plant ingredients can interfere in this regulation
Genetics such as SNPs, epigenetics and microbiota contribute to an individual metabolism and the interaction with nutrition, but also other influences from the environment. A preventive, individualised health care must therefore respect individual characteristics and try to characterise individual metabotypes
Selected literature from our group