Research fields. Concepts:

Complex human phenotypes and diseases are determined by genetics and the environment.

Whereas hereditary influences are considered to be significant, simple single nucleotid Polymorphisms (SNPs) are obviously not of high influence. Gene- environment interactions underlying epigenetics may be of  special importance.

 

 

 

 

 

 

 

Epigenetics is  regulated by three main mechanisms, CpG Methylation,Histone modifications, Interference DNA

 

 

 

 

 

 

 

 

We think that nutrition  affects  basic human molecular function such as  ageing, gut health, CNS -functions, oxydation, inflammation, DNA damage, DNA repair  via the epigenetic system in two ways:

1. directly, by epigenetic and anti-oxidative effects of food ingredients

2. indirectly, by changing gut microbiota and their epigenetic active metabolites

 

 

 

 

 

 

 

 

Interaction between GI microbiota, the gut, the immune system and the gut brain axis are of central importance

for human health and healthy ageing

 

 

 

 

Epigenetic regulation of telomer attrition, anti-oxydative and inflammatory mechanisms, DNA instability and DNA repair as well as inbalances of GI microbiota is of central importance for health. Plant ingredients can interfere in this regulation

 

Genetics such as SNPs, epigenetics and microbiota contribute to an individual metabolism and the interaction with nutrition, but also other influences from the environment. A preventive, individualised health care must therefore respect individual characteristics and try to characterise individual metabotypes

 

 

 

 

 

 

 

 

 

Selected literature from our group

Plant ingredients, epigenetics anti cancer activities

Nutriepigenomics

Epigenetics and inflammation

Epigenetic Marker, breast Cancer

Microbiota,  Metabolites, Butyrate, Epigenetics

Mikrobiota und Probiotika