Research fields. Concepts:

Complex human phenotypes and diseases are determined by genetics, epigentics, nutrition  and the environment.

Epigenetics is  regulated by three main mechanisms, CpG Methylation,Histone modifications, Interference DNA.

The methylation of  the thousands of CpG sites in the genome reflects aging and DNA (in)stability and can be used as a biological clock.

epigenetic clock and environment  >>>

 

We think that nutrition  affects  basic human molecular function such as  ageing, gut health, CNS -functions, oxydation, inflammation, DNA damage, DNA repair  via the epigenetic system in two ways:

1. directly, by epigenetic and anti-oxidative effects of food ingredients

2. indirectly, by changing gut microbiota and their epigenetic active metabolites such as butyrate

 

Interaction between GI microbiota, the gut, the immune system are of central importance for human health and healthy ageing

Microbiota structure and microbiota metabolites  are main elemnts of the gut brain axis

 Epigenetic regulation of telomer attrition, anti-oxydative and inflammatory mechanisms, senescence, autophagy , DNA instability and DNA repair as well as inbalances of GI microbiota are of central importance for health and healthy aging.

Senolytics>>

Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins.

Genetics such as SNPs, epigenetics, microbiota and life style contribute to an individual metabolism and the interaction with nutrition. Definition of metabotypes and individual recommendations fir nutrition and diests need to adrees all these elements.  Unfortunately most commercial metabolic tests only look for genetic characteristics  

Fasting and biological active supplements address mechanisms  which reduce premature aging,  metabolic and cancerogenic hazards.  Autophagy and removal of senescent cells  which contribute  to inflammation and DNA damage are of crucial importance.

Epigenetic active plant ingredients and short chain fatty acids can contribuze to healthy aging but  safety, stability  and bioavailability is of crucial importance

Health care will need to develop in a preventive individualised way

 Our health is affected in countless ways by the environment we live in. In some cases this is more obvious – for example when we look at sooty air pollution – in others less so, like with endocrine-disrupting (EDCs) and other toxic chemicals which are used in many consumer products in our daily lives.

Especially agriculture and health are linked in many ways and with organic farming we  see  possibilities for improving both, environment and human health.

Factors from the  social and natural enironment habe been shown to directly interact with basic mechanism of human health, especially the epigenetic regulation